Purpura henoch schonlein en pediatria pdf document. Frequently, hsp leads to abdominal pain and intestinal bleeding, renal involvement and joint pain. She has torpid evolution, and gastrointestinal and renal complications. A streptococcal antigen in the glomeruli of children with henoch schonlein. Hsp affects the small vessels called capillaries in the skin and frequently the kidneys. Gastroenterology research practice 2010, article id 597648. The role of corticosteroid in hemorrhagic bullous henoch schonlein purpura. The disease is characterized by abnormal deposits of immunoglobulin a an antibody in the blood vessels, leading to their inflammation vasculitis.
Henoch schonlein purpura hsp is an immunemediated vasculitis. Each of the forms of vasculitis tends to involve certain characteristic blood vessels. Henochschonlein purpura hsp is a form of blood vessel inflammation or vasculitis. The small vessels of the skin, joints, kidneys, and digestive organs. Henoch schonlein purpura also known as iga vasculitis is a disorder that causes the small blood vessels in your skin, joints, intestines, and kidneys to become inflamed and bleed. Henoch schonlein purpura presenting as hemorrhagic vesicles and bullae. The iga deposits in vessel walls, associated with the.
Their clinical manifestations included palpable purpura in 100%, subcutaneous edema in 30%, arthritisarthralgia in. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. Henochschonlein purpura symptoms and causes mayo clinic. Severe hemorrhagic bullous lesions in henoch schonlein purpura. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Schonlein henoch purpura is a leukocytoclastic vasculitis, most common in children which affects small vessels. The most striking feature of this form of vasculitis is a purplish rash, typically on the lower legs and buttocks. There are many different conditions that feature vasculitis. Review article the pathogenesis and treatment of pediatric henochschonlein purpura nephritis yukihiko kawasaki received. Penyakit ini ditandai oleh lesi kulit spesifik berupa purpura nontrombositopenik, artritis, nyeri perut dan perdarahan saluran cerna, serta dapat pula disertai nefritis.
Henoch schonlein purpura hsp, also called immunoglobulin a vasculitis igav, is a vascular disease that primarily affects small blood vessels. Henoch schonlein purpura hsp is an immunologically mediated disease associating purpura plus urticaria, characteristically affecting lower limbs, buttocks, and elbows. It predominantly affects the skin, joints, gastrointestinal. Ten years of experience at a moderate risk office of a general hospital a. Thrombocytopenic purpura is mostly responsible for episodes of mucocutaneous bleeding.
1525 1041 157 679 996 885 718 53 709 1590 355 430 961 683 1607 1482 940 323 1050 1253 1023 1533 91 594 1123 32 976 337 1398 1394 72 281 1166 1228 239 1413 672 326